ABSTRACT
Background: Diabetes mellitus, a metabolic disorder of absolute or relative insulin deficiency, is characterized by micro and macro-vascular complications. This process of vascular pathology proceeds at a uniform rate throughout the body. Eventually it may be manifested as atherosclerotic changes in cerebral, coronary and peripheral arteries Variables like central adiposity, altered metabolism, elevated blood pressure, proteinuria causes resistance
Methods: A retrospective cross-sectional study was carried out on 4482 diabetic patients attending the [Diabetes Management Center] Services Hospital, Lahore. Known determinates of past vascular disease PVD were assessed. An artery disease index was formulated by the presence or absence of lower limb pulses
Results: Past history of OVA was significantly associated with PVD with a p-value of 0.002. Similarly past history of M1 [p=0.000], hypertension [p=0.000], proteinuria [p=0.000] were all significantly present in patients with PVD. There was lack of association between cigarette smoking [p= 0.463] and PVD
Conclusion: Past hlstay o! CVA and MI, Hypertension and Protienuria are all significantly present in Diabetic patients with Peripheral Vascular disease
ABSTRACT
Background: Vascular disease Games the maximum mortality and morbidity burden in diabetic patents. Peripheral vascular disease is generally considered to be similar in its etiology and pathology to vascular disease in other tissue fields and its risk factors are also believed to be a part of larger atherogenic vascular picture
Methods: The study was conducted on a cohort of individuals suffering from Diabetes MelIitus registered at the [The Diabetes Management Center]. A total of 1160 cases were selected on the basis of presence or absence of peripheral artery disease with an aim to study the prevalence of peripheral vascular disease In diabetic and ascertain if total cholesterol, age and duration of diabetes play a role in the development of peripheral vascular disease
Results: Our study showed that presence of peripheral vascular disease in diabetics is significant; associated with increased age, increased duration of diabetes, history of intermittent claudication, delayed wound healing and Increased area of skin ulcers. There is no significant difference in total cholesterol level, LDL HDL, and triglyceride levels amongst those diabetics that developed PVD than those who did not The role of genetic susceptibilities leading to altered metabolism with due contribution by environmental factors may come to light by further analysis of other variables involved In artery disease picture
Conclusion: Presence of peripheral vascular disease in diabetics is significantly associated With Increased age Increased duration of dIabetes and history of intermittent claudication, delayed wound heating and increased area of skin ulcers. There is no significant difference in total cholesterol level LDL HDL and triglycerides levels amongst those diabetics that developed PVD than those who did not
ABSTRACT
Background: Diabetes leads to a dysmetabolic state in the body. A cluster of bio chemical and anthropometeric factors have been found to cause pro inflammatory state in vascuIar endothetium. The role of anthropomeric measures in development of atherosclerosis in patients with cardiovascular disease has been extensively studied. The aim of this study is to assess the influence of these factors in peripherai vascular disease
Materials and Methods: Queries were run on a cohort of diabetic patients and anthropometric measurements were made. Peripheral vascular disease was assessed by presence or absence of pulses
Results: The factors found to be significantly different in patients with peripheral vascular diseases versus those without peripheral vascular disease include waist circumference and waist Hip ratio, diastolic, systolic blood pressure and delayed wound healing
Conclusion: Distribution of adipose tissue and its possible endocrine control plays a significant role in subsequent development of vascular Injury and atherosclerosis in Diabetics
ABSTRACT
Objective: To find out whether peripheral artery disease followed the same pattern, set of risk factors and indicators as macro vascular disease in the coronary arteries and cerebral arteries disease
Study design: This was a randomized cross sectional retrospective analysis
Place and duration: Study was carried out at The Diabetes Management Center at The Services Hospital Lahore, during June 1999 to June 2001
Patients and methods: A total of 580 patients were selected from the diabetic data base that had absent pulsations in the any of the four arteries of the lower limbs. Another set of 580 diabetics with presence of pulsations in all the arteries of the lower and upper limbs was randomly selected to match the cases
Results: Diabetics with peripheral vascular disease had a significant positive history of past CVA and past MI
Conclusion: Presence of peripheral vascular disease is significantly associated with presence of history of past CVA and past MI, raised systolic BP, diastolic BP, and mean BP and increased proteinurea